In the year 1471 a member of the Sorbonne, Guillaume Fichet, looking back on the history of what today we should call communication technology, divided it into three periods: antiquity , a subsequent period which we should identify as the Middle Ages , and a period just beginning . Just over five hundred years later an American scholar, Walter J. Ong, looking back on a longer historical span, divided it into orality, writing, printing, and electronic communications. No matter how much (...) these two figures may differ over details, they occupy a similar position: each stands at the start of a communications shift which has alerted him to changes in the past, and Ong claims explicitly that contrasts “between electronic media and print have sensitized us to the earlier contrast between writing and orality.” We do not have to go as far as Eric A. Havelock, who suggests that our new awareness can be precisely dated by a number of publications appearing in the annus mirabilis 1963 , in order to accept the general point that recent work has been stimulated by recent technology. (shrink)

Dennis H. Wrong postulates sociological theory’s origins in the asking of general questions about man and society. Th e answers lose their meaning if they are elaborated without reference to the questions, as has been the case in much contemporary theory. An example is the Hobbesian question of how men become tractable to social controls. Th e two-fold answer of contemporary theory is that man „internalizes“ social norms and seeks a favorable self-image by conforming to the „expectations“ of others. (...) Such a model of man denies the very possibility of his being anything but a thoroughly socialized being and thus denies the reality of the Hobbesian question. Th e Freudian view of man, on the other hand, which sociologists have misrepresented, sees man as a social though never a fully socialized creature. Wrong claims that sociologists need to develop a more complex, dialectical conception of human nature instead of relying on an implicit conception that is tailor-made for special sociological problems. (shrink)

Abstract The concept of culture was originally an expression of German nationalism, which reacted to the French Enlightenment by asserting the uniqueness and incomparability of all cultures as historical creations. This understanding of cultural diversity, which prevailed in American anthropology, is widely understood to imply the moral equality of all cultures. Yet its relativism originally applied to different individuals socialized in the values of their culture, rather than to different cultures. The debate over multiculturalism, which presupposes cultural relativism, ignores this (...) distinction. The vogue of multiculturalism reflects the decline of the Left, quests for community and identity, and an actual reduction in diversity more than a genuine appreciation of different cultures. (shrink)

Abstract Several scholars have observed that in contrast to ?socialism,? ?capitalism? was not an ideology promoted by a social class or movement but an economy that emerged ?spontaneously? from particular historical conditions. Since the decline of the Soviet Union, no new version of socialism has been promulgated, although complaints about the inequalities of capitalism inevitably persist and will certainly continue. Capitalism, if not ?eternal,? remains a highly probable form of economy under conditions of economic surplus, extensive division of labor, urbanism, (...) and the absence of fully centralized state power. An inevitably wide variation in its forms will certainly endure and in no way amounts to the ?end of history,? as a few writers have suggested. (shrink)

Adolescence is a time of transition from childhood to adulthood during which significant changes occur across multiple domains, including emotional experience. This article reviews the relevant literature on adolescents’ experience of four specific dimensions of emotion: emotional frequency, intensity, instability, and clarity. In an effort to examine how emotional experiences change as individuals approach adulthood, we examine these dimensions across ages 10 to 19, and review how the emotional functioning of adolescents compares to that of adults. In addition, we explore (...) whether and how gender and puberty explain age differences in emotional experience. Finally, we discuss how these findings could inform future research on both the typical trajectory of emotional experience and the development of psychopathology in adolescence. (shrink)

In the face of mounting criticism against advance directives, we describe how a novel, computer-based decision aid addresses some of these important concerns. This decision aid, Making Your Wishes Known: Planning Your Medical Future , translates an individual's values and goals into a meaningful advance directive that explicitly reflects their healthcare wishes and outlines a plan for how they wish to be treated. It does this by (1) educating users about advance care planning; (2) helping individuals identify, clarify, and prioritize (...) factors that influence their decision-making about future medical conditions; (3) explaining common end-of-life medical conditions and life-sustaining treatment; (4) helping users articulate a coherent set of wishes with regard to advance care planning—in the form of an advance directive readily interpretable by physicians; and (5) helping individuals both choose a spokesperson, and prepare to engage family, friends, and health care providers in discussions about advance care planning. (shrink)

In November of 1959, William Bean published in the Archives of Internal Medicine a scathing review of Félix Martí-Ibañez’s Centaur: Essays on the History of Medical Ideas. Martí-Ibañez and Bean were two of the leading exponents of the importance of medical humanism during a formative period from the 1950s through the 1970s. But the two physicians differed fundamentally in their views of the ideal relationships among the pharmaceutical industry, the medical profession, and the medical humanities. We situate Bean’s review within (...) its historical context, shedding light on the history and diverging uses of the medical humanities. (shrink)

Skeletal myoblasts have their origin early in embryogenesis within specific somites. Determined myoblasts are committed to a myogenic fate; however, they only differentiate and express a muscle‐specific phenotype after they have received the appropriate environmental signals. Once proliferating myoblasts enter the differentiation programme they withdraw from the cell cycle and form post‐mitotic multinucleated myofibres (myogenesis); this transformation is accompanied by muscle‐specific gene expression. Muscle development is associated with complex and diverse protein isoform transitions, generated by differential gene expression and mRNA (...) splicing. The myofibres are in a state of dynamic adaptation in response to hormones, mechanical activity and motor innervation, which modulate differential gene expression and splicing during this functional acclimatisation. This review will focus on the profound effects of thyroid hormone on skeletal muscle, which produce alterations in gene and isoform expression, biochemical properties and morphological features that precipitate in modified contractile/mechanical characteristics. Insight into the molecular events that control these events was provided by the recent characterisation of the MyoD gene family, which encodes helix‐loop‐helix proteins; these activate muscle‐specific transcription and serve as targets for a variety of physiological stimuli. The current hypothesis on hormonal regulation of myogenesis is that thyroid hormones (1) directly regulate the myoD and contractile protein gene families, and (2) induce thyroid hormone receptor‐transcription factor interactions critical to gene expression. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

In East Asia, there has been a long tradition of using graphs and diagrams to express abstract ideas. This paper is to give an account of the East Asian methodsfor representing body, mind and the universe. The fundamental ideas of East Asian graphic interpretation mostly originated from the Yijing (I Ching, Zhouyi), and were later developed by Confucian and Daoist thinkers to describe the universe, the mind, and the body as an organic totality. By comparing different approaches to portraying the (...) universe, this paper offers a critical analysis of East Asian semiotics. (shrink)

In East Asia, there has been a long tradition of using graphs and diagrams to express abstract ideas. This paper is to give an account of the East Asian methodsfor representing body, mind and the universe. The fundamental ideas of East Asian graphic interpretation mostly originated from the Yijing (I Ching, Zhouyi), and were later developed by Confucian and Daoist thinkers to describe the universe, the mind, and the body as an organic totality. By comparing different approaches to portraying the (...) universe, this paper offers a critical analysis of East Asian semiotics. (shrink)

A study of the tradition of ethical socialism, its successes, its failures, and its relevance to contemporary Britain. It focuses on a group of writers who, although separated by time, all promoted this brand of socialism. It chronicles their thoughts and theories, and examines their intentions.

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)